Brain metastases in a large UK Cancer Centre: Trends over a decade, 2000 to 2010
Connie Yip, Clary Evans, Vicky Goh and David Landau
World Journal of Epidemiology and Cancer Prevention 2013, 2:2
Brain metastasis has a significant impact on care provision. Our aim was to investigate the trend in primary site and survival of patients with brain metastases over a 10-year period in a large UK cancer centre.
Materials and Methods
259 patients with a radiological diagnosis of brain metastases in 2000, 2005 and 2010 were identified from our institutional database. 16 patients were excluded due to inadequate diagnostic information with 243 patients included in the final analysis. Year of brain metastases diagnosis and primary tumour sites were correlated with overall survival (OS) using Kaplan-Meier analysis and comparisons between groups were performed using log-rank test. Fisher exact test was used to test for significant associations between year of brain metastases diagnosis and primary tumour sites. A p value
<0.05 was considered significant.
56 (23%), 95 (39%) and 92 (38%) patients were diagnosed with brain metastases in 2000, 2005 and 2010, respectively. There were higher proportion of patients with lung cancer (2000, 2005, 2010: 41%, 43%, 50%), melanoma (2%, 10%, 8%) and renal cell carcinoma (RCC) (2%, 4%, 6%) in 2005 and 2010 compared to 2000 (p = 0.009). OS for patients diagnosed in 2010 (median OS (MOS) 3.8 months) were longer compared to those diagnosed in 2005 (MOS 2.8 months) and 2000 (MOS 1.5 months, p=0.007).
Survival of patients with brain metastases has improved over the past decade. Breast and lung cancers remain the commonest primary tumours with brain metastases with a small increase in the number of patients with melanoma and RCC.
Brain metastases; trend; survival; primary tumours.