World Journal of Medical Research Volume No 6

Original Article Open Access

Association of E-selectin A561C (S128R) and G98T gene polymorphism with essential hypertension in a Chinese population: a meta-analysis

Li Yan-yan
World Journal of Medical Research 2013, 2:2

Abstract

Background

Gene polymorphism is considered to contribute in the etiology of essential hypertension (EH). In particular, E-selectin (SELE) gene is one of the candidate genes susceptible to EH. Moreover, SELE A561C (S128R) and G98T gene polymorphisms have been suggested to be associated with the increased risk of EH, but the results are still inconsistent.

Material and methods

The present study aims to evaluate the association of SELE A561C and G98T gene polymorphisms with EH. Nine separate studies on the relationship of SELE A561C and G98T gene polymorphisms with EH were analyzed through meta-analysis. Among these studies, five were for A561C with 1662 subjects, and four studies were for G98T with 1356 subjects. Pooled odds ratio (OR) and its corresponding 95% confidence interval (95% CI) were calculated using the fixed effect model.

Results

SELE A561C and G98T gene polymorphisms were found to be significantly associated with EH under a dominant genetic model and an allelic genetic model. The pooled ORs for AC+CC/AA genotype, frequency of C allele, GT+TT/GG genotype, and frequency of T allele were 2.39 (95% CI: 1.68–3.39, P < 0.00001), 2.07 (95% CI: 1.50–2.86, P < 0.00001), 1.63 (95% CI: 1.07–2.47, P = 0.02), and 1.51 (95% CI: 1.01–2.26, P = 0.04), respectively.

Conclusions

The current meta-analysis suggests that the SELE gene polymorphisms of the C allele and CC genotype of A561C as well as the T allele and TT genotype of G98T might be related to EH susceptibility in the Chinese population.

Keywords

E-selectin, A561C, G98T, gene polymorphism, hypertension, meta-analysis.




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