World Journal of Medical and Surgical Case Reports Volume No 6

Case Report Open Access

Bilateral Angiosarcoma of Breast

Seema Khanna, Shashi Mishra, Chandan Jha, Satendra Kumar and Sanjeev K Gupta
World Journal of Medical and Surgical Case Reports 2013, 2:22



Sarcoma of the breast is a rare tumor with poor prognosis. Majority of the cases described in literature are secondary to radiotherapy. Fine needle aspiration cytology is a good tool for diagnosis. Optimal treatment for breast sarcoma is still unclear.

Case Report

A 25 years female presented with a recurrent 10x8 cm lump in her left breast. Systematic examination of the contralateral breast revealed a 4 x3 cm lump in her right breast also. FNAC suggested the possibility of a malignant mesenchymal lesion. Bilateral simple mastectomy was performed. Histopathology revealed bilateral angiosarcoma of the breast with extensive haemorrhage and necrosis. Immunohistochemistry was positive for Vimentin and CD 31 but negative for S 100. Adjuvant chemotherapy (MAID regime) was given to the patient.


Primary sarcoma of the breast usually presents as a lump with variegated consistency in the breast in a young female often secondary to radiotherapy. FNAC is diagnostic. Angiosarcoma is the most common variant. 5 year survival ranges from 40%-91 %. Margins of surgical resection are an important prognostic indicator. Axillary dissection is generally thought to be unnecessary for soft tissue sarcomas.


Adequate surgical excision, grade and tumor diameter seem to be the most important prognostic factors.

Key Words

Sarcoma, Breast, Mastectomy, chemotherapy

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