World Journal of Pathology Volume No 6

Original Article Open Access

p53 is not expressed in Indian salivary gland neoplasm: A light microscopic and immunohistiochemical retrospective review of 140 salivary gland neoplasms

Mridula Shukla, N Laila Raji, M Radhakrishnan Pillai, Ruhi Dixit and Manoj Pandey
World Journal of Pathology 2012, 1:12



Salivary gland neoplasms are a heterogeneous group of tumours with different biological behaviour.

Patients and Methods

A retrospective analysis of gross and light microscopic features of 140 salivary gland neoplasms treated at Government Medical College, Trivandrum was carried out. Immunohistiochemistry for p53 was performed for 15 benign and 15 malignant salivary neoplasms.


A total of 140 cases were studied during this period. Mean age of the patient was 43 year (SD +16.5) year; ranging from 7 to 87 years. There were 66 (47.1%) females and 74 (52.9%) males. Pleomorphic adenoma was commonest in 54.3%, followed by Warthin’s tumour in 15%, pleomorphic adenoma with myoepithelial predominance in 7.9% of the cases. Among the malignant neoplasm mucopidermoid carcinoma was commonest in 7.9%. p53 immunostaining was not observed in any of the cases.


p53 expression is not seen in Indian salivary cancers, this could be due to selection bias or a true negativity.

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