Adenosquamous cancer of the oesophagus arising from Barrett’s metaplasia: a review of the pathophysiology and treatment options
Kumuthan Sriskandarajah, Mikael H Sodergren, Jane Weston and Paras Jethwa
World Journal of Pathology 2013, 2:12
In this article we report a case of adenosquamous carcinoma arising from Barrett’s metaplasia, only the 6th clinical report of this entity in the literature, and we review the pathophysiology that may underlie its development. Given the rarity of this tumour the optimal treatment is largely unknown but the prognosis appears relatively poor. Given that the most recent data suggests a significant survival benefit from neo-adjuvant chemotherapy in adenosquamous carcinoma and, with phase III trials supporting the use of trimodality therapy, conventional neoadjuvant cisplatin-based chemoradiotherapy followed by surgical resection remains the recommended treatment of choice until further data is available.
Adenosquamous, Barrett’s, Carcinoma, Oesophagectomy, and Treatment