World Journal of Pathology Volume No 6

Original Article Open Access

Anti CCP Antibody Assay: A Diagnostic Dilemma in Diagnosis of Tubercular Synovitis

Abhijeet Kunwar, Saurabh Singh, Usha Singh and Neha Chaurasia
World Journal of Pathology 2014, 3:7



Anti-CCP antibodies assays have been reported to be a specific diagnostic marker than rheumatoid factor in the diagnosis of rheumatoid synovitis. There may be diagnostic dilemma if anti CCP antibody assays are also positive in cases of tubercular synovitis. In this study we look for prevalence of anti CCP in cases of active tubercular synovitis of knee and compare it with controls.


Serum levels of anti CCP antibodies were measured in 31patients of tubercular arthritis of knee and were compared with equal number of age matched controls.


A total of 38.7% of tubercular arthritis patients showed positive results on serum anti CCP antibody assay and the mean of anti CCP levels in patients of tubercular arthritis was more than that in the control group


Anti CCP assay for diagnosis of rheumatoid synovitis may give false positive results in patients of tubercular arthritis


Test for anti CCP antibody is positive in many patients of tuberculous synovitis.


Tuberculosis, rheumatoid arthritis, false positive

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