World Journal of Pathology Volume No 10
Original Article
Anti CCP Antibody Assay: A Diagnostic Dilemma in Diagnosis of Tubercular Synovitis
Abhijeet Kunwar, Saurabh Singh, Usha Singh and Neha Chaurasia
World Journal of Pathology 2014, 3:7
Abstract
Objective
Anti-CCP antibodies assays have been reported to be a specific diagnostic marker than rheumatoid factor in the diagnosis of rheumatoid synovitis. There may be diagnostic dilemma if anti CCP antibody assays are also positive in cases of tubercular synovitis. In this study we look for prevalence of anti CCP in cases of active tubercular synovitis of knee and compare it with controls.
Methods
Serum levels of anti CCP antibodies were measured in 31patients of tubercular arthritis of knee and were compared with equal number of age matched controls.
Results
A total of 38.7% of tubercular arthritis patients showed positive results on serum anti CCP antibody assay and the mean of anti CCP levels in patients of tubercular arthritis was more than that in the control group
Discussion
Anti CCP assay for diagnosis of rheumatoid synovitis may give false positive results in patients of tubercular arthritis
Conclusion
Test for anti CCP antibody is positive in many patients of tuberculous synovitis.
Keywords
Tuberculosis, rheumatoid arthritis, false positive
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