Mesectodermal Leiomyoma: A Unique Morphology, Revisiting the Embryogenesis
Shramana Mandal, Kaushik Majumdar, Ravinder Saran and Sushil Kumar
World Journal of Pathology 2015, 4:1
Mesectodermal leiomyoma connotes a tumor originating from the smooth muscle of the ciliary body, a mesodermal tissue derived embryologically from the neural crest (ectoderm). The tumor recapitulates its ancestral embrogenic pathway, bearing the histomorphology quite different from the usual fascicular architecture comprising of myogenic spindle cells of a leiomyoma originating from the smooth muscles at other locations. We present a case of 19 year-old female presenting with a history of progressive loss of vision in the left eye for last 8-10 months. Histopathologic features were those of leiomyoma of the ciliary body with strong immunohistochemical expression of smooth muscle actin. Thus, leiomyomas arising from the ciliary body are rare specialized tumors, recapitulating the mesectodermal ancestry. Early diagnosis and timely surgical intervention is necessary to prevent complications.