World Journal of Pathology Volume No 8

Research Open Access

Prognostic Validity of Agnor in a Diaspora of Maxillofacial Fibro-Osseous Lesions

Bacem AE Ottoman, Iman M. Helmy, Ayman A. Amin and Mohamed H. El-Malahy
World Journal of Pathology 2015, 4:5


Fibro-osseous lesions of the jaws comprise a diverse, interesting, and challenging group of conditions that pose difficulties in classification and treatment. Common to all is the replacement of normal bone by a tissue composed of collagen fibers and fibroblasts that contain varying amounts of mineralized substance, which may be bony or cementum-like in appearance. All were stained with H&E to confirm the diagnosis in addition to the argyrophilic nucleolar organizer region staining stain (AgNOR) to conduct the morphometric study. This study investigates 20 cases of fibrous dysplasia (FD), 35 cases of peripheral ossifying fibroma (POF), 20 cases of central ossifying fibroma (COF), 5 cases of ossifying fibromyxoid tumor, as well as 10 cases of normal mucosa as a control group. One-way ANOVA (ANalysis Of VAriance) with post-hoc Tukey HSD (Honest Significant Differences) tests were calculated to compare between the mean AgNOR score of area fraction of the studied lesion. Pearson’s correlation (r) test and its P-Value were calculated between the mean AgNOR score of area fraction and duration of every lesion.


Fibro-osseous lesions, AgNOR stain, fibrous dysplasia, ossifying fibroma, morphometric analysis.

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