World Journal of Pathology Volume No 6

Review Open Access

A review of Carcinoma ex Pleomorphic Adenoma of the salivary glands

Saeedeh Khalesi
World Journal of Pathology 2016, 5:2



One of the malignant forms of pleomorphic adenomas (PA) is carcinoma ex pleomorphic adenoma (CA-ex-PA). Carcinoma ex pleomorphic adenoma is an uncommon malignant tumor with high aggressive behavior and poor prognosis. However, there are a few studies in this topic in the recent literature. Furthermore, the lesions are uncommon and often have a difficult diagnosis by clinicians and pathologists, because the residual small PA component and various malignancy subtypes may be present. In this study, we reviewed the recent studies in about clinical, radio graphical, histopathological and molecular features of CA-ex-PA.


In this review article, the studies were identified by researches on three databases- Pubmed, MEDLINE, and Google scholar- from 2005 through 2015 in the English language for the carcinoma ex pleomorphic adenoma. We used the following search terms: "carcinoma ex pleomorphic adenoma, salivary gland tumors". We included original studies and review articles.


Recently, much research have been performed to study, a review of development and progression of carcinoma ex pleomorphic adenoma which have been identified already.


CA-ex-PA is an uncommon malignant tumor with the particular biological behavior in contrast to the other salivary gland neoplasm. It is important to be aware of the tumor and early detection of pleomorphic adenoma is important for the prevention of CA-ex-PA.


Salivary gland tumors, Carcinoma ex pleomorphic adenoma, Histopathology

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