World Journal of Surgical Medical and Radiation Oncology Volume No 6

Original Article Open Access

Unusual Variants of Diffuse Large B - Cell Lymphoma at Extranodal Sites. - Are These Distinct Diagnostic Entities

Hema Malini Aiyer
World Journal of Surgical Medical and Radiation Oncology 2013, 2:13

Abstract

Context

Diffuse Large B  - Cell  Lymphoma  (DLBCL)  is  a  heterogenous  category of  Mature  B- Cell  Neoplasms  in the  updated  2008  WHO  Classification. We Present  here  the  more  uncommon  variants  in unusual  locations  that  have  unique  Clinicopathologic  features  and  which  the  author  believes  are  possibly  distinct  biologic  entities  in  our  experience.

Objective

We  highlight  here  the  Clinicopathologic  and Immunohistochemical features  of  a  few of  the  more  uncommon  variants  and  also  discuss  actual  scenarios  and  practical  difficulties  encountered  in  cases  presenting  to our  institution  

Data  sources  

Material  from  the  author's  institution, CAP  Protocol  for  the  examination  of  specimens  from  patients   with  Non – Hodgkin's  Lymphoma /  Lymphoid  neoplasms,  literature  from  Pub  Med  and  the  WHO  Classification  of tumours  of  hematopoietic  and  lymphoid  tissues  2008.  

Conclusions  

While  WHO  recognizes  several  morphologic  and   clinical  subtypes  of  DLBCL,  their  distinction  and  categorization  and  site  specific  features  remain difficult  to  reproduce,  lack  of consensus among  reporting  pathologists  further  hampering  accurate  delineation.  Many  variants  moreover,  clubbed  under  the  rubric  of  DLBCL  NOS  probably  are  distinct  biologic  entities,  which  need  to  be  recognized  as  such.




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