World Journal of Surgical Medical and Radiation Oncology Volume No 6

Case Report Open Access

Hyperinsulinemic Hypoglycemia due to Diffuse Nesidioblastosis in Adults

Nan Xiang, Chi-hua Fang, Ying-fang Fan and Jian Yang
World Journal of Surgical Medical and Radiation Oncology 2013, 2:5



Nesidioblastosis is a rare cause of adult-onset hyperinsulinemic hypoglycemia. We describe a 28-year-old lady who presented with sudden loss of consciousness. Hyperinsulinemic hypoglycemia was found.

Material and Methods

Preoperative imaging’s and intraoperative ultrasound failed to identifiy any pancreatic insulinoma. Selective intra-arterial calcium stimulation with venous sampling showed an elevated insulin level within the distal splenic vein. Open distal pancreatectomy was performed.


Histopathology confirmed nesidioblastosis.


Her recovery was uneventful.


Hyperinsulinemic hypoglycemia; Adult nesidioblastosis; Distal pancreatectomy, insulinoma.

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