Hereditary gastric cancer – diagnosis and clinical implications
Tomasz Banasiewicz, Zoran Stojcev and Andrzej Plawski
World Journal of Surgical Medical and Radiation Oncology 2014, 3:1
Gastric cancer is still one of the world's leading causes of cancer mortality. Approximately 10% of gastric cancers appear to have a familial predisposition. In this this group, 1-3% are considered as hereditary syndromes, with a clear genetic pathway, associated with the most important mechanisms of the CDH1 germline mutations. This mutation lead to the hereditary diffuse gastric cancer syndrome (HDGC). Other syndromes of familial prevalence of the gastric cancer, correlated with genetic mutations, are the hereditary nonpolyposis colorectal cancer, Li-Fraumeni syndrome, Peutz-Jeghers syndrome, Familial Adenomatous Polyposis, Cowden disease. Families HDGC can be identified and tested for causative mutations in CDH1, in other syndromes screening gastroduodenoscopy is indicated.