Survivin Expression and Correlation with Clinico-pathological Parameters in Breast Cancer
Kumkum Jha, Mohan Kumar, Vijay K Shukla and Manoj Pandey
World Journal of Pathology 2012, 1:6
Introduction: Survivin is an intracellular, multifunctional protein which controls cell proliferation, inhibition of apoptosis and the promotion of angiogenesis. Present study deals with expression of survivin in fibroadenoma and breast cancer and correlation of its expression with other clinico-pathological parameters.
Materials and Methods: Survivin expression was measured by Immunohistochemistry, Western Blotting and RT PCR in 29 cases of fibroadenoma and 91 breast cancer .
Results: Survivin mRNA was present in 44.8% of fibroadenoma and 72.5% of breast cancer cases while survivin protein was expressed in 41.3% of fibroadenoma and 63.7% of breast cancer. Survivin expression showed significant correlation with tumor Stage, histological Grade, estrogen receptor (ER), and HER2 status .
Conclusion: Increased survivin expression at gene level might serve as a diagnostic and prognostic marker in breast cancer and can be used as a therapeutic target.