World Journal of Pathology Volume No 6

Case Report Open Access

Necrotic Pseudoxanthomatous Nodule: An Unusual and Less Known Manifestation of Endometriosis

Kiran Agarwal, Deepti Verma, Anamika Kashyap and Archna Rautela
World Journal of Pathology 2014, 3:15


Necrotic pseudoxanthomatous nodule (NPN) is an uncommon manifestation of endometriosis. It grossly presents as nodules over peritoneal surfaces. Histopathologically, it is marked by presence of a central area of necrosis surrounded by hyalinization and histiocytes arranged in a palisaded fashion along the periphery of the necrotic area. These histiocytes have abundant granular or foamy cytoplasm. It represents the end stage endometriosis. Here we are reporting two such cases. It is important to know about this entity as it can be confused with necrotic tumor or infectious pathology, to avoid misdiagnosis in the absence of more classical features of endometriosis and from management point of view.


necrotic pseudoxanthomatous nodule, endometriosis, necrosis, histiocytes

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