Giant cells in giant cell reparative granuloma: physiognomic or pathognomic relevance?

Bacaem AE Ottoman
World Journal of Pathology 2015, 4:6

Abstract

Giant cell reparative granuloma is a tumor-like lesion, which is characterized by the typical appearance of dotted granulation tissue. Such dotting is attained by the giant cell populations. Histogenesis and pathogenesis of such multinucleated giant cells are, hitherto, controversial. Some attributed the origin of multinucleated giant cells to an osteoclastic lineage from differentiated mononuclear cells. This paper, however, suggests another origin with a newly introduced mechanism of action.

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