Original Article

Impact of Body Mass Index on Treatment Outcomes of Adjuvant Radiation Therapy in Saudi Females with Endometrial Carcinoma

Mushabbab AlAsiri, Mutahir A Tunio, Abdulrehman AlHadab, Reham Mohamed, Yasser Bayoumi, Eyad Alsaeed and Abdullah AlAmro
World Journal of Surgical Medical and Radiation Oncology 2012, 1:22

Abstract

Background

Aim was to evaluate the impact of body mass index (BMI) on locoregional control (LRC), distant metastasis control (DMC), disease free survival (DFS) and overall survival (OS) in patients with endometrial carcinoma (EC) treated with adjuvant radiotherapy.

Materials and methods

Between June 2006 and July 2011, 66 patients with EC received adjuvant radiotherapy. Median age was 58.02 years (40-88). Mean BMI was 35.9 kg/m² (23-72); BMI < 24 kg/m² (normal weight) in 3 (4.5%), BMI 25-30 kg/m² (overweight) in 19 (28.8%), BMI 31-40 kg/m² (obese) in 20 (30.3%) and BMI > 40 kg/m² (morbid obese) in 24 (36.4%).

Results

Median follow-up was 55 months (6-60). The Kaplan-Meier estimates of LRC, DMC, DFS and OS were 83.3%, 74%, 78.6% and 66.3% respectively. Patients with BMI > 30 kg/m² showed inferior LRC (74.5%-80%) with p 0.003 and inferior OS (55%-61.4%) with p value 0.001. No influence of BMI on DMC and DFS was seen { hazard ratios of 0.97 (0.78-1.24) and 0.99 (0.81-1.26) respectively}. There was positive correlation of daily treatment setup errors with BMI > 30 kg/m² (p 0.001). No correlation with found between BMI and radiation toxicity.

Conclusion

Patients with EC and high BMI had inferior LRC and OS. Emphasis shall be given on adjustment of setup errors during radiotherapy and on implementation of a national obesity prevention program.

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